実験的脳虚血における局所脳血流量と脳波の関連

CORRELATION BETWEEN LOCAL CEREBRAL BLOOD FLOW AND EEG IN EXPERIMENTAL CEREBRAL ISCHEMIA

　抄録　ラットの各段階の虚血脳モデルを作製し，皮質および尾状核部での局所脳血流量を水素クリアランス法にて測定した。又，同じ電極針を用いて脳波を記録し，パワースペクトル分析を行った。局所脳血流量が，10ml／100g／min以上あれば，脳波のデルタパワーパーセントと，脳血流量には負の相関関係が認められた。

　今後，臨床例においても，持続脳波モニターにより虚血部位における脳血流量を予測出来るものと思われる。

Varying degrees of cerebral ischemia were pro-duced in adult Wistar rats by clipping of bilateral common carotid arteries with or without induced hypotention. Local cerebral blood flow was meas-ured from bilateral caudate nuclei and parietal cortices using the hydrogen clearance method. EEG was recorded from the same electrode as used for the hydrogen clearance method. The delta power of EEG increased along with decreasing local cere-bral blood flow. There was an inverse correlation between the delta power of EEG and local CBF values, ranging from normal to extremely low (10 m//100g/min). When local CBF was reduced below 6-8 m//100g/min, EEG became isoelectric. Con-tinuous EEG recording might contribute to predict rCBF value in the ischemic lesion.