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抄録 脳腫瘍のホルモン依存性については髄膜腫,神経鞘腫が女性にに発生頻度が高いこと,妊娠により症状が消長することより想像されて来た。そこで我々は髄膜腫(Mg),神経鞘腫(Nn)につきエストロゲン・レセプター(ER)を検索した。内訳はMg15例(男2,女13),Nn5例(男3,女2)である。測定方法は摘出腫瘍をホモゲナイズし,その248,800×g上清をcytosolとした。cytosolと3H-estradiolおよび, それらに非放射性estradiolを加えたものを4℃で120分incubateし,遊離形ステロイドをcharcoalにて吸着後,charcoal法にて結合量を求めScatchard plotを作製し,最大結合部位数(Bm:fmol/mg cytosolProtein),解離定数(Kd:×10—−10M)を検討した。MgにおけるERは女性において,閉経前で4/5(80%)に陽性でBm=20.8±12.2,Kd=2.8±0.7,閉経後は2/8(25%)に陽性でBm=22.8,Kd=6.9であった。男性例にはERを検出できなかった。Nnは男性1例(20%)のみにBm=25.0,Kd=2.3を検出した。髄膜腫,神経鞘腫の一部にはERが存在することよりエストロゲンに対して感受性があるものと推測される。
In the brain tumors hormone dependency has long been suggested from the evidence that men-ingiomas and neurinomas are frequently seen in female and that they enlarge during pregnancy presumably as a result of hormonal change. Recent-ly the presence of estrogen receptor (ER) in meningiomas, neurinomas and pituitary adenomas were documented in some preliminary reports.
In this report we estimated the ER in the tissue of 15 patients with meningiomas (13 females and 2 males) and 5 with neurinomas (2 females and 3 males). The estrogen receptor level was determined by Scatchard analysis. The results were obtained as follows: In meningiomas, 80% (4/5) of premeno-pausal females, 25% (2/8) of postmenopausal femals and 0% (0/2) of males had receptor activity. Maxi-mal binding sites (Bm; fmol/mg cytosol protein) and dissociation constant (Kd;×10-10M) are as fol-lows: Bm=20.8±12. 2(premenopause;n=4) or 22.8 (postmenopause;n=2) and Kd 2.8±0.7 (premenopause) or 6. 9 (postmenopause). In neu-rinoma, 33% (1/3) of males and 0%(0/2) of females had receptor activity. Bm and Kd are as follows: Bm=25.0 and Kd=2. 3. The ER detectable rate in meningiomas was much higher in premenopausal females.
There was a suggestion that some brain tumors are responsible to estrogen via cellular estrogen receptor.
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