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Japanese

ESTROGEN RECEPTORS IN MENINGIOMAS AND NEURINOMAS Masahito Fujimoto 1 , Eiji Yoshino 1 , Satoshi Ueda 1 , Kimiyoshi Hirakawa 1 , Hiroshi Kusanishi 2 , Yosuke Ohono 2 , Teruhiko Tamaya 2 1Department of Neurosurgery, Kyoto prefectural University of Medicine 2Department of Obstetrics and Gynecology, Kyoto prefectural University of Medicine pp.399-404
Published Date 1982/4/1
DOI https://doi.org/10.11477/mf.1406204927
  • Abstract
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In the brain tumors hormone dependency has long been suggested from the evidence that men-ingiomas and neurinomas are frequently seen in female and that they enlarge during pregnancy presumably as a result of hormonal change. Recent-ly the presence of estrogen receptor (ER) in meningiomas, neurinomas and pituitary adenomas were documented in some preliminary reports.

In this report we estimated the ER in the tissue of 15 patients with meningiomas (13 females and 2 males) and 5 with neurinomas (2 females and 3 males). The estrogen receptor level was determined by Scatchard analysis. The results were obtained as follows: In meningiomas, 80% (4/5) of premeno-pausal females, 25% (2/8) of postmenopausal femals and 0% (0/2) of males had receptor activity. Maxi-mal binding sites (Bm; fmol/mg cytosol protein) and dissociation constant (Kd;×10-10M) are as fol-lows: Bm=20.8±12. 2(premenopause;n=4) or 22.8 (postmenopause;n=2) and Kd 2.8±0.7 (premenopause) or 6. 9 (postmenopause). In neu-rinoma, 33% (1/3) of males and 0%(0/2) of females had receptor activity. Bm and Kd are as follows: Bm=25.0 and Kd=2. 3. The ER detectable rate in meningiomas was much higher in premenopausal females.

There was a suggestion that some brain tumors are responsible to estrogen via cellular estrogen receptor.


Copyright © 1982, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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