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APPLICATION OF FLOW CYTOMETRIC ANALYSIS TO BRAIN TUMOR CHEMOTHERAPY. : REPORT 1 : CHANGES OF CELL KINETICS INDUCED BY ANTICANCER DRUGS Kazuhiro Nomura 1 , Hiroaki Yamamoto 1 , Soichiro Shibui 1 , Yoshimasa Miki 1 , Masako Seki 1 1Department of Neurosurgery, National Cancer Center Hospital pp.341-350
Published Date 1981/4/1
DOI https://doi.org/10.11477/mf.1406204739
  • Abstract
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It has been reported that flow cytometric analy-sis offers good indicators to select drugs for chemo-therapy of malignant neoplasms, however, there are still few reports to try to apply these data to clinical treatment. For this purpose perturbation of cell cycle traverse which induced by several anticancer drugs was studied to determined the fun-damental factors to indicate the sensitivity of each drugs.

Results were :

1) Drugs showed high efficiency of accumulation of cells in SG2M phase even in low concentra- tion ; MMC, AD, CQ.

2) Drugs showed high efficiency of accumulation of cells in SG2M from low concentration to high concentration ; Vincristine.

3) Drugs which showed accumulation of SG2M in high concentration ; ACNU, BCNU.

9L rat glioma cells treated with BCNU showed high efficiency of acumulation of cells in SG2M phase. In this cell line cytocidal effect was high. However, C6 cells which showed low accumulation in SG2M even by treatment with high concentration of BCNU revealed quite resistant to anticancer drugs from nitrosourea derivatives (ACNU, BCNU). Cytocidal effect of MMC and ACNU on C6 glioma cells was studied by colony foming efficiency assay using multicell spheroids treated with these drugs and it was discussed the correlation between percent of accumulated cells and cytocidal effect of each drug.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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