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Brain and Nerve No to Shinkei Volume 35, Issue 10 （October 1983）

Brain and Nerve 脳と神経 35巻10号（1983年10月発行）

Japanese English

原著

各種脳腫瘍におけるpyrimidine nucleoside phosphorylase活性と5´—DFURによる治療の可能性 PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE ACTIVITIES IN BRAIN TUMORS AND ANTITUMOR EFFECT OF 5´-DFUR 渋井壮一郎 ¹ , 渡辺卓 ² , 三木啓全 ² , 野村和弘 ² , 三輪昌敬 ³ Soichiro Shibui ¹ , Takashi Watanabe ² , Yoshimasa Miki ² , Kazuhiro Nomura ² , Masanori Miwa ³ ¹東京大学脳神経外科 ²国立がんセンター脳神経外科 ³日本ロシュ研究所微生物学化学療法部 ¹Department of Neurosurgery, University of Tokyo Hospital ²Department of Neurosurgery, National Cancer Center Hospital ³Department of Microbiology and Chemotherapy, Nippon Roche Research Center pp.1017-1022

発行日 1983年10月1日 Published Date 1983/10/1

DOI https://doi.org/10.11477/mf.1406205204

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Abstract 文献概要
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　抄録　原発性および転移性脳腫瘍36例，正常脳10例について，生物検定法によりpyrimidine nucleosidephosphorylase活性を測定した。Sarcolna 180をactive control （100％）として各腫瘍の酵素活性値の平均を表わすと，glioblastoma 39.3, astrocytoma22.0,oligodendroglioma 9.7, meningioma 22.4であり，正常脳は8.5以下であった。glioma系腫瘍では酵素活性の高い症例ほど術後生存期間が短く，転移性脳腫瘍においては原発巣の診断から脳転移出現までの期間が高活性の症例ほど短い傾向を示し，いずれも活性値と臨床悪性度との関連性を示していると思われた。一般にこの酵素は小腸・胃などを除いた正常組織では極めて活性が低いと言われているため，この酵素によってはじめて5—FUに変換され抗腫瘍効果を発揮する5´—deoxy−5—fluorouridine （5´—DFUR）は，脳を含む正常組識に及ぼす影響が少なく，しかも悪性脳腫瘍に対し，効果的な化学療法剤のひとつとして期待できるものと考えられる。

Activities of pyrimidine nucleoside phospho-rylase in brain tumors were measured and their relationship to a clinical course of the patients was investigated.

Pyrimidine nucleoside phosphorylase is said to exist more quantatively in malignant tumors such as Sarcoma 180, Ehrlich ascites carcinoma, Walker 256, and hepatoma, and very little in normal tis-sues.

In brain tumors the activities were measured by bioassay and compared to that of Sarcoma 180. When the activity of Sarcoma 180 was expressed to be 100%, those of brain tumors were as fol-lows : ten cases of normal brain less than 8.5 ; six cases of glioblastoma 39.3±30.7 ; five cases of astrocytoma 22. 0±13.8 ; five cases of meningioma 22.4±13.7; two cases of oligodendroglioma 8.1 and 11. 3 ; two cases of sarcoma 94. 3 and 145.4 ; chordoma 48. 0 ; ependymoblastoma 3. 7 ; plexus papilloma 22.5 ; parotid cancer 43.4 ; ten cases of metastatic brain tumors from lung cancer 61.5ｱ 41. 6 ; two cases from breast cancer 28.0 and 68.8 ; that from thyroid cancer 10. 0 ; that from gastric cancer 13.5 ; malignant melanoma 77.2.

In 12 cases of gliomas (glioblastoma, astrocy-toma, oligodendroglioma) the mean activity was highest in glioblastoma (39. 3), followed by astro-cytoma (22. 0) and oligodendroglioma (9. 7). The postoperative survival time became shorter in gli-omas with the higher activities.

In metastatic brain tumors from lung, breast, and gastric cancer, the average time from the diagnosis of primary cancer to brain metastasis was shorter in cases with high activities and longer in cases with low activities.

5'-deoxy-5-fluorouridine (5'-DFUR) is a newlysynthesized masked compound of 5 FU, which is converted to 5 FU with the existence of pyrimi-dine nucleoside phosphorylase. Because the acti-vity of the enzyme is high in malignant brain tumors and low in normal tissues including brain, 5'-DFUR is expected to be one of the effective antitumor drugs for the treatment of malignant brain tumors.