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Brain and Nerve No to Shinkei Volume 30, Issue 8 （August 1978）

Brain and Nerve 脳と神経 30巻8号（1978年8月発行）

Japanese English

原著

家兎前頭葉kindlingならびに，その視覚・聴覚誘発電位に及ぼす影響 FRONTAL KINDLING IN RABBITS AND ITS INFLUENCE ON VISUAL AND AUDITORY EVOKED RESPONSE 鶴紀子 ¹ , 国吉昌長 ² , 井手之上純三 ² Noriko Tsuru ¹ , Masanaga Kuniyoshi ² , Junzo Idenoue ² ¹宮崎医科大学精神医学教室 ²鹿児島大学医学部神経精神医学教室 ¹Department of Psychiatry, Miyazaki Medical College ²Department of Neuropsychiatry, School of Medicine, Kagoshima University pp.843-851

発行日 1978年8月1日 Published Date 1978/8/1

DOI https://doi.org/10.11477/mf.1406204285

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Abstract 文献概要
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I．はじめに

　kindling PhenomcnonはGoddard^1,2）により見い出され，微弱の電気刺激を繰りし与えることによつて，後放電の延長，自発性の棘波出現終には全身痙攣発作を示すものである。実験動物も，下等動物よりrat^{1，2，13，14，16,26）}，cat^{2,3,6,20,23,28,30,31）}，Papio papio^29,33），monkey^2）に及んでいる。刺激部位も，そもそもは扁桃核^{1〜3,7,13,1416,29〜31,33）}であつたが，海馬^17,18），中隔部^21），前頭葉^{15,32，34）}と多岐にわたつている。

　kindling preparationを用いた実験てんかんの研究はその後次第に発展し，側頭葉発作との関連を論じたものを始め，刺激の影響が，刺激局所にとどまらず，脳の他の部位へ及び，その結果生ずる転移現像^7,18），さらには深部脳幹^27,31）への影響などのsecondary epileptogene—sis^10,11）を論じたもの，抗痙攣剤の作用解明のための実験モデルとして用いたもの^33）や，その他，脳内カテコーラミンとの関連を論じたもの^20）がある。

In our earlier stud ofy interictal dysfunction of epileptic brain, we showed the topological dif-ference of recruiting response following epilepto-genic focus formation. In this paper, we showed the daily frontal kindling in rabbits developed the elongation of afterdischarge accompanied with clinical feature development, and primary, dependent and/or independent mirror focus formation. And the visual and auditory evoked response were ex-amined.

Daily electrical stimulation (300 μA, 60Hz, 1msec, 2sec train) of the frontal cortex showed that rab-bits were kindled in that site. Clinical features were divided 5 stages. Those were :

1) No response or attention response.

2) Adversive movement with or without exten-tion of left forelimb and clonic convulsion

3) Adversive movement with mastication, saliva-tion, oral twitching with postictal akinetic state.

4) Fall down following generalized convusion.

5) Generalized convulsion with rotatory movement, vocalization and myoclonus.

The durations of afterdischarge were ranged from 2 or 3sec. on stage 1 to 400sec. on stage 5. The durations of afterdischarge were not constant even though on stage 5.

In the auditory evoked response, the second posi-tive component (P²: 73.3 msec), and the second negative component (N²: 146.7 msec) were shortened in peak latency in kindled group compared with control group. And the amplification of N² com-ponent was recognized. On the other hand there was no significant change in the visual evoked re-sponse. Therefore, there was a discrepancy be-tween the change of the visual and the auditory evoked response.