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NORMAL PRESSURE HYDROCEPHALUS : Part 1.DYNAMIC STUD OF CSF CIRCULATION IN PATIENTS WITH NORMAL PRESSURE HYDROCEPHALUS Motoki Baba 1 , Eiji Takeyama 1 , Toshio Beppu 2 , Minoru Jimbo 1 , Koiti Kitamura 1 1Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical College pp.505-513
Published Date 1978/5/1
DOI https://doi.org/10.11477/mf.1406204244
  • Abstract
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To clarify the pathogenesis of normal pressure hydrocephalus (NPH), quantitative measurement of CSF dynamics was attempted using RI techniques.

In this study results concerning RI ventriculo-graphy and RI transfer test from CSF to plasma were reported."Barrier ratio"and regional cerebral blood flow study in NPH will be reported else-where. Fifty-three patients with chronic com-municating hydrocephalus were devided into two groups. Thus, twenty-seven cases were diagnosed as NPH according to clinical symptoms and signs, and others were considered as mere chronic com-municating hydrocephalus without any NPH char-acteristics.

Results are as follows;

1) 169Yb-DTPA ventriculography; In NPH group, there was longer retention of RI injected into lateral ventricle, and RI activity was not de-tected in the cisterna magna 60 minutes after the injection. These findings show remarkable delay of CSF flow in NPH patients.

2) Transfer test of 169Yb-DTPA from CSF to plasma; Immediately after the RI injection, trans-fer ratio of RI activity from CSF to plasma was measured. It was revealed that intraventricular RI was more rapidly transfered to plasma in NPH group compared with in the control group, sug-gesting accelerated trans-ependymal absorption of RI in NPH group.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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