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Japanese

ANTIEPILEPTIC ACTIVITY OF CLONAZEPAM:A BENZODIAZEPINE ANTIEPILEPTIC Ⅱ. EFFECTS OF INTRAVENOUS INJECTION OF CLONAZEPAM Toshinori Mori 1 , Hideaki Kato 1 , Sumie Ikeda 1 , Ikuo Morizaki 2 1Department of Neuropsychiatry, School of Medicine, Gifu University 2Department of Psychiatry, Nagara National Hospital pp.171-180
Published Date 1977/2/1
DOI https://doi.org/10.11477/mf.1406204020
  • Abstract
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Clonazepam, a new anti-epileptic agent was intra-venously injected into 23 patients with paroxysmal activity in the interictal period and anti-epileptic effects of clonazepam were evaluated in terms of changes in EEG.

1) There was little influence on the basic rhythm with improvement observed only in 4 cases (19%). As there was a case which was aggravated by clonazepam therapy showing a trend toward slow waves on EEG, the paradoxical possibility of clonazepam for clinically inducing seizures was discussed.

2) Generalized paroxysmal waves were restrained with clonazepam in 81. 8% of the subjects. It was shown that clonazepam was more intensive in the effect restraining generalized paroxysmal waves than focal paroxysmal waves.

3) Clonazepam was remarkably effective on 4 cases out of 6 with temporal spike. The effect of clonazepam on this kind of waves was described. 4) Clonazepam was effective on all cases with photosensitivity. Based on the findings, it was emphasized that clonazepam exerts strong restrain-ing effects on photosensitivity.

5) Based on the comparison with the effects of the intravenously administered diazepam in 5 cases, it was proved that the effect of clonazepam is maintained longer than that of diazepam.

6) In some half number of the subjects, muscle relaxation and drowsiness were induced as adverse reactions. The blood pressure was found lowered by roughly 10%.

7) Satisfactory therapeutic results were obtained with the intravenously administered clonazepam in 4 cases with status epilepticus.


Copyright © 1977, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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