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EFFECT OF TRIETHYLTIN ON POTASSIUM-STIMULATED OXYGEN UPTAKE OF RAT BRAIN CORTEX SLICES Keishi Kobayashi 1 , Shozo Nakazawa 1 1Department of Neurosurgery Brain Research Institute, Niigata University pp.1039-1044
Published Date 1971/9/1
DOI https://doi.org/10.11477/mf.1406202968
  • Abstract
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Slices of rat brain cortex were incubated in Krebs-Ringer phosphate medium with 10 mM glucose, and the respiratory activity was measured using the standard Warburg manometric technique. After 30 minute-incubation, the concentration of KCl in themedium was elevated to 105 mM to estimate the potassium effect. To study the effect of triethyltin (TET), TET-sulface was added to the medium or it was injected intraperitoneally to rats at the daily dose of 2 mg/kg body weight for one to three days.

1) When TET was added at lower concentration (5 × 10-6 More), the oxygen uptake of rat brain cortex slices was slightly increased in normal media, but it was supressed in media containing 105 mM KCl (which stimulates normal brain respiration.)

2) Similarly with administration of TET in vivo, oxygen uptake of rat brain cortex slices was inhibited to a greater extent in media containing 105 mM KC1 than in normal media.

3) While rat liver slices and rat brain cortex homogenate were not supressed by TET to a greater extent in the presence of 105 mM KC1 than in normal media.


Copyright © 1971, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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