大脳基底核石灰化を呈した特発性副甲状腺機能低下症の1例

A CASE OF IDIOPATHIC HYPOPARATHY-ROIDISM ASSOCIATED WITH CALCI-FICATION OF THE BASAL GANGLIA

I．はじめに

　特発性副甲状腺機能低下症は，本邦においては，昭和31年，佐野^1）の報告以来10例の記載を見るにすぎず，さらに，本症に合併する大脳基底核石灰化については，本邦報告例を見ない。われわれは最近，ballism様不随意運動，四肢強直性痙攣発作を主訴とし，大脳基底核石灰化を伴つた特発性副甲状腺機能低下症のまれな例を経験した。

A 35-year-old housewife of idiopathic hypopara-thyroidism was reported. She had had epileptic con-vulsions since 12 years and involuntary movements as like as ballisms on her both legs, right shoulder and face, about one year. She had also complained of blurred vision due to bilateral cataracts.

Remarkable bilateral calcifications of the basal ganglia were revealed roentgenologically. On the laboratory examinations low serum calcium (2.4 mEq/l), high serum phosphate (8. 3 mg/dl), low phosphate clearance (4.4 m//min), and high tubular reabsorption of phosphate (94.4 %) were revealed. Ellsworth-Howard test with intravenous injection of 200 units of Parathormon was 5.2 times positive.

The convulsions and involuntary movements were stopped temporarily by the injection of Diazepam and disappeared by the administration of Diazepam, calcium lactate and vitamin D₂. The serum calcium returned to normal level.