損傷脳修復機転に及ぼす各種薬剤の影響について

EXPERIMENTAL STUDIES ON AFFECTS OF DRUGS ON AMENDMENT AND MOTIVATION OF IMPAIRED BRAINS

I．緒言

　わが国における最近の脳神経外科の進歩はめざましく，その手術適応もますます拡大されつつあり，また他方，産業，経済の近代化とともに交通事故その他の災害による脳損傷患者も近年激増の傾向にある。このような手術あるいは外傷による脳損傷に接する機会が多くなつた昨今，この方面に各種の新しい薬剤が数多く登場してきた。すなわち脳浮腫に対するステロイド製剤，細胞代謝賦活剤としてのチトクロームC，リン脂質代謝賦活剤としてのCDP-cholin，網内系賦活剤のソルコセリルなどである。これらの薬剤の一般的適応とされる患者数が多いだけに，いずれも臨床的に広く用いられるものであるが，実際の臨床で，これらの薬剤をどのように使いわけてゆくかということはなかなか困難な問題であろう。私どもはこのたび実験的に脳創を作り，その回復過程を組織化学的に検索することによつて，これら薬剤の脳創修復に及ぼす影響を検討し，ひいては脳損傷時の薬物の投与法を検討したのでここに報告する。

The existence of glycogen in the brain has been substatiated by many doctors concerned, and it is a known fact that its existence practically coincides with the recovery of the function of the brain. The affects of drugs on the amendment and motication of impaired brains were histochemically studied by observing the status of the glycogen in the brain.

The following are the experiments conducted to obtain necessary data for treatment of impaired brains.

1. The type of groups experimented :

a. Contrast group.

b. The drug administered groups:

(1) Cytochrome C. 0.0012 mg/g/clay

(2) Solcoseryl 0.01 mg/g/day

(3) Predonin 0.004 mgjg/day

(4) CDP-choline 0.01 mg/g/day

c. The chemical inhalation groups :

2. The results of the experiments :

a. The administration of :

(1) Cytochrome C. indicated significant affects on both the granulation of glyco-gen and the recovery of bioreaction.

(2) Solcoseryl indicated the affects on the granulation of glycogen appearing at acomparatively earlier stage than that of the contrast group, and moderate affects on the recovery of bioreaction.

(3) Predonin indicated the affects on the granulation of glycogen to be significant, and although, the affects on the action and reaction on the recovery of bioreac-tion were satisfactory, a delay was noticed in the absorption of food.

(4) CDP-choline indicated significant af-fects on both the granulation of glycogen and the recovery of bioreaction.

b. The inhalation of :

(1) Oxygen indicated significant affects on both the granulation of glycogen and the recovery of bioreaction.

(2) Carbon dioxide indicated significant af-fects on the granulation of glycogen, and moderate affects on the recovery of bi-oreaction.

(3) Mixed gas indicated significant affects on both the granulation of glycogen, and the recovery of bioreaction.