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CLINICAL MEASUREMENT OF CEREBRAL HEMODYNAMICS WITH RADiOISOTOPES:Brain Transit Time as an Index of Cerebral Hemodynamics Masami KITANO 1 1Dept. of Neurosurgery, Keio Univ., School of Medicine pp.117-124
Published Date 1967/2/1
DOI https://doi.org/10.11477/mf.1406202171
  • Abstract
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1) Brain transit times were studied in normals by an intravenous radioisotope technique utilizing external monitoring of brain passage of a bolus of nondiffusible radioactive indicators. This transit time (or brain pool turnover time) was used as an index of brain blood flow.

2) Brain transit time is 10 seconds in average in healthy subjects with a general increase in advanced age. Brain transit time is also prolonged by hyper-ventilation and Valsalva effect.

3) Differential rate of passage of brain transit time of plasma and red cell were studied respectively. Red cell transit time is faster than plasma (mode value 7 seconds vs 5 second, mean value 8 seconds vs 5 second).

4) Frequency distribution of transit time of plasma and red cell were measured and its significance was discussed.

5) Clinical significance of brain transit time was discussed as an index of cerebral hemodynamics.


Copyright © 1967, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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