中枢神経系賦活調整作用をもつCentrophénoxineの基礎的研究

Fundamental Studies of Centrophénoxine

I．はしがき

　クロールプロマジンの出現以来，向精神剤の開発は誠にめざましいものがある。

　最近ヨーロッパ系の文献に散見するCentrophénoxine （ANP 235）の臨床報告は，昏睡等の意識障害に卓効を示すという点において，臨床家の注目をひくものがある。

Authers studied the fundamental actions of Centro-phénoxine, new drug which is considered to readjust the disturbances of consciousness.

The results obtained in the rabbit are as follows:

1) ECG: Intravenous injection of 10 mg/kg Centro-phénoxine (clinical dose) does not give any change in ECG. In large dosis (50 mg/kg), this drug causes the bradycardia but nutill administration of 100 mg/kg, there is no obvious ECG signs of coronary insufficiency, myocardial damage and conduction block.

2) Blood pressure: Rapid injection or injection of high concentrated Centrophénoxine induces the transient falling of blood pressure. In the caseof slow injection the blood pressure falling is very slight.

3) Microcirculation of pia matter: The alternation of the microcirculation in the pia matter is consider-able: after injection of Centrophénoxine, both arteriole and venule show dilatation and true capillaries becomes visible.

4) EEG: Centrophénoxine does not affect the normal EEG. The EEG changes induced by Nembutal, Urethane-Chloralose and Chlorpromazine are ameliorated by intravenous injection of Centro-phénoxine and goes into the remarkable activation pattern.