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HISTOCHEMISTRY OF THE BRAIN:LIGHT-AND ELECTRON-MICROSCOPIC Nobuo Shimizu 1 1Dept. of Anatomy, Osaka Univ. Medical School pp.5-17
Published Date 1964/1/1
DOI https://doi.org/10.11477/mf.1406201587
  • Abstract
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Histochemical studies of the mammalian brain have been made with reference to me-tabolism of carbohydrate and chemical trans-mitters. Main results obtained are as follows:

1) Large amounts of relatively stable gly-cogen are demonstrated in the paraventricu-lar structures (area postrema, supraoptic crest and subfornical organ) and hypothala-mus.

2) Although these regions exhibit a weak activity of succinic dehydrogenase and cyto-chrome oxidase, they give marked activity of lactic and glucose-6-phosphate dehydroge-nase.

3) Strong activity of monoamine oxidase is shown in the paraventricular structures and autonomic regions of the brain, moderate one being in the limbic system.

4) Electron histochemical studies of mo-noamine oxidase show that this enzyme is located in the lysosomal dense body of the nerve cell bodies and neuropil. Acetylcholine-sterase is demonstrated in the endoplasmic reticulum of nerve cell bodies and in the pre-and postsynaptic membrane of the synapses.

5) Granulated vesicles can be found in large numbers within the synaptic terminals in the hypothalamus and paraventricular structures but hardly found in the striatum.

6) Radioautographic studies show that la-beled 5-hydroxytryptphan and serotonin are mainly incorporated within the neuropil, and sparsely within the nerve cell bodies.


Copyright © 1964, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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