Japanese
English
- 有料閲覧
- Abstract 文献概要
- 1ページ目 Look Inside
1)Cafergotを片頭痛患者30例と神経性頭痛患者5例に投与し,片頭痛患者21例に有効であつたが,神経性頭痛患者には無効であつた。
2)Cafergotは片頭痛発現機序に影響を与え,片頭痛頓挫薬として特有な効果を示し,かつ片頭痛の診断に役立つ。
3)Cafergotは片頭痛脳波所見上安静時は正常所見,賦活時に正常あるいは軽度異常所見を示すものに特異的な効果があつた。安静時より異常所見,賦活時に中等度以上の異常所見を示すものには,Cafergotより抗癩癇剤の方が有効であつた。この事は片頭痛の概念規定にも影響し今後に残された重要な問題である。
4)Cafergotの初回投与時間は片頭痛発作の前駆期或は発作発現と同時に投与すると効果があるが,この時期より遅れると無効である。
5)Cafergotの副作用の出現頻度は比較的少くかつ軽度である。そして薬剤の中止或は減量又は他剤との混合で容易に消槌する。
6)片頭痛患者は特有な精神的素因をもち,それによつて片頭痛発作を誘発する傾向があるので,薬剤の投与と同時に精神療法,生活指導が不可欠である。
Cafergot was effective for 21 of 30 cases of migraine examined but it was not effec-tive for 5 cases of neurotic headache.
The effect of Cafergot is supposed to have some relationships with pathogenetic mecha-nisms of migraine and has a prompt effect, so that it will be also useful for the thera-peutic diagnosis of migraine. Cafergot is spe-cially effective for the cases which have al-most normal E. E. G. findings at rest and ab-normal findings only by activation. The ca-ses which showed abnormal E. E.G. findings at rest or severe pathological E. E.G. findings by activation are refractory to Cafergot. Anti-convulsants are more effective for such cases.
Cafergot is most effective when it was given at the prodrcmal stages or at the onset of attack. Later administration of this medicine is not effective.
Few cases showed side effects with Cafer-got, but they were mild and controled easily by the interruption or reducing in dosage orby combination with other medicines. As the patients of migraine have charac-teristic mental disposition, not only the me-dication, but psychotherapy and guidance in daily life are indispensable for their treat-ment.
Copyright © 1961, Igaku-Shoin Ltd. All rights reserved.