クリプトコックス脳膜炎の1剖検例

THE HISTOPATHOLOGY OF CRYPTOCOCCUS MENINGITIS

　真菌症は，抗生物質，コーチゾン等の使用と共に注目されてきた疾患であるが，一方，診断及び菌体検索の進歩により，その報告は最近著しい増加を示している。

　我々は，3年来時折頭痛を訴えていた患者が突然，高熱，頭痛，吐気，嘔吐，意識障害等，脳炎様の症状を呈して1カ月後に死亡し，剖検によりCryptococcus脳膜炎である事を確認した1例を経験したのでここに報告する。

A case of cryptococcus meningitis, histo-pathologically verified, was reported.

A 59-years-old man complained of head-aches since three years, followed by sudden onset of encephalitic symptoms associated with pyrexia, headache, nausea and conscious disturbance, and he died one month after the onset of the encephalitic symptoms.

Macroscopically, slight clouding of pia ma-ter was shown.

Microscopically, perivascular infiltration of lymphocytes with round cells, histiocytes, epitheloid cells, phagocytes and giant cellswas found all over the subarachinoid cavity, particulary on pia mater, having organism among these cells. Such change extended into the cerebral cortex along blood vessels, and tubercle like nodule was present with lymphocytes, histiocytes, epitheloid cells and giant cells around blood vessels of the under-lying cortex, markedly localized in Virchow-Robin's space. While cerebral destructure was slight and cortical structure was also well maintained, there was in cerebellum widespread necrosis, which supposed to be followed by vascular change.