頭部外傷後遺症患者のヒロポン負荷試験

PERVITIN TEST IN RESIDUAL HEAD INJURIES

　16名の脳外傷後遺症患者，11名の脳震盪後遺症患者，3名の頭蓋外傷患者，計30名の頭部外傷患者に対し，ヒロポン2cc（0.0006g）を静注し，負荷試験を行つたところ，意識溷濁，入眠傾向，潜在的神経症状の増強又は出現，血圧一脈搏の背理的変化，自律神経症状の出現，など，種々の異常反応が認められた。これらは，正常には認められぬ反応であるが，脳外傷後遣症の殆んどにあらわれ，脳震盪後遺症では少数にみられ，頭蓋に外傷を受けたのみのものでは全くみられなかつた。しかも，これは神経症的色彩（心気症，誇張，ヒステリー機構）とは全く無関係にあらわれる。しかも，その反応の異常は全く質的なものであり，量的偏奇ではない。このような点より考えて，ヒロポンによる負荷試験は頭部外傷後遺症の検査に際し，有力な補助的診断法となりうると思われる。

An attempt has been made to clinically de-velop the latent residual disturbances of head injuries by an intravenous administration of 6 mg. of Philopon (=Pervitin). Thirty cases have been studied.

They showed the following abnormal reac-tions: Development of latent neurological sy-mptoms, cloudiness of consciousness and dro-wsiness, dissociation of blood pressure and pulse rate, and abnormal autonomic reactions. These abnormal reactions are observed in most of the brain-injured (14 cases out of 16) and in some cases with history of commotio cerebri (4cases out of 11). No abnormal reacti-ons are seen in the cases with neither brain injuries nor history of commotio cerebri. No neurotic factors are referable to the above-mentioned abnormal reactions. The present study seems to eloquently advocate Faust-Frowein's report (Dtsch. Zschr. Nervenhk., 164, 66, 1950) which asserte Pervitin Test to be a most favoradle method for the differen-tial diagnosis of residual head injuries.