新抗酒剤Citrated Calcium Carbimideの臨床経験

CLINICAL EXPERIENCES WITH CITRATED CALCIUM CARBIMIDE, A NEW ANTI-ALCOHOSISM AGENT

　Carbimide （＝Cyanamide）の誘導体であるCitrated Calcium Carbimide （C．C．C．）は，Lederle Laboratories Inc．によつてTemposil　と名称され，一新抗酒剤として登場した。

　Temposilは1953年にFergusion^1）によつて発見されたものである。発見のいとぐちは^4），最近10年間アルコール中毒患者の治療剤としてJa-cobsen等により使用し始められたAntabuseの示す，好ましからざる副作用を除去する目的の研究の結果，発見された。従つて，本剤はAntabuseの補助剤^2）3）として，亦新抗酒剤として賞用されつつある。我々は今回日本レダリー株式会社の好意によりTem　posilを使用する機会を得たが，1957年8月以来の臨床経験を取り纒めて茲に報告する。

Since August 1957, the authors have been engaged in this study. Temposil (Lederle),a slow release tablet, being a combination of calcium carbimide and citric acid, was given to 5 cornal adult volunteers, 3 psychopathicsand 16 alcoholics, totaling 24, in the present report of experiments.

At tirst, the typical Temposil-alcohol rea-ction, both subjective and objective, which was obtained by the authors as the results of experiences of 50-odd test dose, was men-tioned. And then, some comparisons between both Temposil-alcohol and Antabuse-alcohol symdroms were made. Finally, twenty four actual cases of abstinence by use of this drug were described in detail.

Basing upon the above-mentioned data, the pharmacological action of Temposil was com-mented trom various standpoints of view, to-gether with the effective dose of Temposil,the method of administration, and the tech-nique of testing.

Temposil might, the authors concluded, be considered useful not only as an adjuvant to Antabuse but also as a new independent anti-alcoholism agent, because there were only negligible side-effects. The Temposil treat-ment should, of course, be combined with ps-ychotherapy.