新抗酒剤Citrated Calcium Carbimide （Temposil）による禁酒療法

TREATMENT OF ALCOHOLISM WITH A NEW ANTIALCOHOLISM AGENT CITRATED CALCIUM CARBIMIDE (TEMPOSIL)

　Georges Malignacがいうように，アルコール中毒はたしかに古くからの問題であるが，今日でも新しい問題として提出されている。

　わが国においても，戦後増加の一途を辿りつつあるアルコール中毒による社会的弊害は，いまや若年者にも浸透しつつあり，現実に今日の問題として等閑視できない現況にあるものといえよう。

The subjects for our present studies with Temposil numbered 18, all were male, rang-ing in age from 24 to 61 years. Thirteen of them were chronic alcoholism, 2 were psy-chopaths, 2 were manic-depessive psychosis that were in a manic state, and 1 was schizo-phrenic, and Temposil was administered in dose of 50 to 100mg. daily for 14 to 43 days, giving a test dose of alcoholic drink once a week, as a rule.

1) A general picture of the clinical and laboratory results following Temposil is given follows:Blood pressure: The drop of systolic pressure was not so intense as after Antabuse. Pulse: Rise in pulse rate was very prominent increasing to more than 100 beats per minutes in almost all the cases. The electrocardiographic studies did not indi-cate abnormal pathologic features. Electroencephalography: No particular chan-ge was observed electroencephalographically following the test doses. Blood and urinary studies and liver function tests: No singnificant pathologic changes we-re noted.

2) We had no side effects following Tem-posil administration both bodily and mentally so far been encountered.