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An Autopsy Case of Argyrophilic Grain Dementia with Abundant Neurofibrillary Tangles Kenichi Oshima 1,3 , Kuniaki Tsuchiya 2,3 , Shuji Iritani 1,3 , Hideki Ueno 1,3 , Kazuhiro Niizato 1,3 , Ryosuke Nakamura 1,3 , Tetsuaki Arai 1,3 , Haruhiko Akiyama 1,3 , Kenji Ikeda 1,3 1Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital 2Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital 3Department of Psychogeriatrics, Tokyo Institute of Psychiatry Keyword: argyrophilic grain dementia , argyrophilic grain , tangle only dementia , neurofibrillary tangle , limbic region pp.133-138
Published Date 2003/2/1
DOI https://doi.org/10.11477/mf.1406100439
  • Abstract
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 We reported an autopsy case of “senile dementia" showing neuropathologically abundant neurofibrillary tangles(NFT) and argyrophilic grains(AG) without senile plaques. A Japanese woman developed memory disturbance when she was 70 years old. The patient was hospitalized at age 80 and a cranial CT scan revealed bilateral mild atrophy of the temporal lobes and mild enlargement of the lateral ventricle, especially in the inferior horn. She died at the age of 80. Autopsy showed that her brain weighted 1220g. Numerous NFT were found in the entorhinal(trans-entorhinal) region, subiculm, CA1-CA4, dentate gyrus, amygdala, nucleus basalis of Meynert, substantia nigra, and locus coeruleus. Furthermore, numerous AG were seen in the temporal lobe(T3, T4),a mygdala, prominently in the basolateral nuclei. Obvious neuronal loss with gliosis was noted in the temporal lobes, including the hippocampal regions. Few senile plaques was detected in temporal lobe(T4). Sarkosyl-insoluble tau extracted from the temporal lobe consisted predominantly of four-repeat tau isoforms. To our knowledge, this is the first report of argyrophilic grain dementia complicated with tangle only dementia.


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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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