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Immunosuppressive-associated Encephalopathy in Bone Marrow Transplant Recipients Keiko Ohta 1 , Asako Yoritaka 1 , Hisashi Sakamaki 2 , Shuji Kishida 1 1Department of Neurology, Tokyo Metropolitan Komagome Hospital 2Department of Hematology, Tokyo Metropolitan Komagome Hospital 3Bone Marrow Transplantation Group Keyword: bone marrow transplantation , immunosuppressive agents , encephalopathy pp.395-401
Published Date 2004/5/1
DOI https://doi.org/10.11477/mf.1406100281
  • Abstract
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 We studied clinical features of immunosuppressive (cyclosporine, tacrolimus) associated encephalopathy in bone marrow transplant patients. 378 cases of allogeneic bone marrow transplant recipients over fifteen years old of chronic and acute leukemia(CML, ANLL, ALL)(n=311), myelodysplastic syndrome (MDS) (n=42) and severe aplastic anemia(SAA)(n=25) were investigated. Immunosuppressive associated encephalopathy occurred in 12 cases. The rate of incidence was significantly higher in SAA and MDS(7 cases) than in leukemia. The cases which showed typical radiological abnormality in MRI were limited in SAA and hypoplastic MDS. 10 cases died, which revealed worse than an overall survival rate of recipients without immunosupressive-associated encephalopathy. 5 of 7 cases in SAA and MDS had taken cyclosporine as treatment of the disease before bone marrow transplantation and that might influence the incidence of encephalopathy.

(Received : January 13, 2004)


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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