パモ酸ヒドロキシジンによると思われる緊張病の1例

A Case of Catatonia Associated with the Ingestion of Hydroxyzine

要旨　推定7 gのヒドロキシジンを服用し意識障害となった26歳の男性が，昏迷と興奮の相反する症状，筋緊張，diazepamにより改善する無呼吸状態を呈し，緊張病と診断した。鎮静・筋弛緩剤と人工呼吸器を用いた呼吸器管理を3日間実施した後，症状は改善した。ヒドロキシジン誘発の緊張病と考えられ，その発症機序を考察した。

A twenty-six-year male who presented with a consciousness disturbance induced by the ingestion of an estimated 7g of hydroxyzine. He demonstrated bipolar symptoms which consisted of both stupor and excitement, and both an increase in muscle tension and apnea, however, these symptoms improved after the infusion of diazepam. He was diagnosed to demonstrate catatonia. After treatment composing three days of mechanical ventilation in combination with the administration of sedatives and muscle relaxatants, his symptoms improved. Hydroxyzine is thus considered to be able to induce catatonia and this mechanism of this condition is discussed.

（Received : September 22, 2004）