パーキンソン病および躁うつ病が多発した1家系

A Family with Frequent Occurrence of Parkinson's Disease and Manic-Depressive Illness

　【抄録】同一地域出身で，母親が姉妹（第Ⅰ世代）といういとこ同士2組（第Ⅱ世代）が結婚した1家系において，その子供9名（第Ⅲ世代）中4名にパーキンソン病または躁うつ病（パーキンソン病は59歳男性，56歳女性；躁うつ病は70歳男性，68歳女性）が認められた組と，7名（第Ⅲ世代）中1名にパーキンソン病（64歳男性）が認められた組について報告した。同一家系内にパーキンソン病と躁うつ病（またはうつ病）が発生したという報告は極めて少数ながらみられ，この両疾患が遺伝的に近縁である可能性を示唆しているが，本家系も同様な観点から極めて興味深い。

　Two of nine siblings from parents of a cousin marriage were diagnosed as having Parkinson's disease (59 y/M, 56 y/F), and another two were diagnosed as having manic-depressive illness (70 y/M, 68 y/F). 0ne of another group of seven siblings was diagnosed as having Parkinson's disease (64 y/M). None of these five patients showed a combination of the two diseases.

　A few families with frequent occurrence of Parkinson's disease and manic-depressive illness have been reported. Those cases reported previously and the present cases suggest that there may he genetic and biochemical associations between the two diseases.