Electroconvulsive Therapy in Advanced Parkinson Disease Patients with Psychosis Tomonori MURAYAMA 1 , Kengo HYAKUMACHI 1 , Toru HAYAKAWA 1 , Seiju KOBAYASHI 2 , Takeshi MATSUOKA 3 1Department of Neuropsychiatry, Date Red Cross Hospital, Date, Japan 2Department of Neuropsychiatry, School of Medicine, Sapporo Medical University 3Department of Neurology, Date Red Cross Hospital Keyword: Parkinson disease , Depression , Delusion , Impulse control disorder , Electroconvulsive therapy pp.677-684
Published Date 2016/8/15
DOI https://doi.org/10.11477/mf.1405205212
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 We retrospectively examined the effectiveness of electroconvulsive therapy (ECT) in six patients with severe Parkinson disease (PD) who showed psychiatric symptoms. Our study demonstrated that psychiatric symptoms were significantly less severe after ECT, as indicated by a change in the Neuropsychiatric Inventory score (Mean±SD, 12.3±9.8 vs. 1.8±2.1). Furthermore, these patients showed significant improvement in Hoehn-Yahr stage after ECT (4.5±0.5 vs. 3.7±0.5). Three patients experienced clinical remission of depression, visual hallucinations, delusions, and impulse control disorders for more than a year. In addition, these three patients also showed improvement in their activities of daily living for more than a year. Three patients with gait impairment were able to walk, and two of these patients could walk for at least year. In these patients, the total daily levodopa equivalent dose was significantly decreased (519.2±224.1mg vs. 242.1±200.0mg). Adverse events were generally mild, with transient retrograde amnesia occurring in two patients. We conclude that ECT is safe and has a beneficial effect in the advanced stages of PD.

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