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A Case of Corticobasal Syndrome Presenting with the Mirror Sign Hideaki SHIMIZU 1 , Kazuhiko HOKOISHI 2 , Yasutaka TOYOTA 3 , Kenjiro KOMORI 4 , Manabu IKEDA 5 1Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Toon, Japan 2Department of Psychiatry, Japan Self Defense Forces Hanshin Hospital 3Department of Psychiatry, Niihama Foundation Hospital 4Department of Clinical Psychology, Niihama Foundation Hospital 5Department of Neuropsychiatry, Faculty of life Sciences, Kumamoto University Keyword: Mirror sign , Corticobasal syndrome , Visuospatial perceptual-motor skills , Self-cognition , Emotional responses pp.161-169
Published Date 2016/2/15
DOI https://doi.org/10.11477/mf.1405205117
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 The mirror sign is a phenomenon in which individuals mistake their reflection in a mirror for another person, and then speak to or abuse the reflection. However, they recognize other people correctly in the mirror. The mirror sign is usually reported in patients with Alzheimer's disease (AD). The neural basis of the mirror sign is unclear because it usually present during advanced stages of AD, when there is diffuse cortical atrophy. Here, we report for the first time, a 53-year-old female patient with corticobasal syndrome presenting with the mirror sign. Although the patient could recognize her image in a hand mirror, she mistook her reflection in a wall mirror for someone else. She showed markedly impaired visuospatial perceptual motor skills, including orienting apraxia of her body and constructional disability. Recognition of oneself in a wall mirror, when the reflection appears abruptly, requires higher visuospatial perceptual-motor skills than does recognizing oneself in a hand mirror, which is habitually used in daily living. Recent imaging studies of nerve function suggest that self-cognition correlates with right cerebral hemisphere function, and with the functional synchronization system of cortical midline structures, called the default mode network. This case suggests that dysfunction of cerebral regions associated with self-cognition facilitates the development of the mirror sign. However, the neural basis of the mirror sign cannot be simply explained by damage to the cerebral regions that form functional networks, because it only appears in 5.46% of patients with AD. Both psychosocial and biological factors play an important role in the appearance of psychiatric symptoms associated with dementia. Therefore, our neuropsychological findings in this case suggest that marked impairments of visuospatial perceptual-motor skills and self-cognition progress to development of the mirror sign by triggering emotional responses such as anxiety and depression.


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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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