精神分裂病患者の血清中の単純ヘルペスウイルス1型に対する抗体について

Serum Prevalence and Geometric Mean Titres of Herpes Simplex Type 1 Virus Antibody in Schizophrenic Inpatients

　抄録　精神分裂病患者243名と対照群314名の血清中の単純ヘルペスウイルス1型（HSV 1）抗体を中和法で測定し，その陽性率及び平均抗体価を比較した。陽性率は加齢に伴って増加し40歳台以上では精神分裂病患者でやや低い傾向を示し，陽性者のみの平均抗体価もやはり加齢に伴って徐々に増加し，精神分裂病患者の全年齢群で対照群よりやや高値を示したが，有意差は認められなかった。さらに精神分裂病群を病型別に細区分して対照群と比較したが，有意差は認められなかった。

　次いで，精神分裂病とウイルスとの関連について文献的に考察を加えた。

　Serum specimens from 243 schizophrenic inpatients and 314 controls were collected for neutralization test of herpes simplex type 1 virus (HSV 1) with a cytopathic HSV 1 strain. The prevalence of HSV 1 antibody correlated with age and, when this was allowed for, no significant differences emerged between schizophrenic inpatients and controls, although the number of inpatients over 40 years old was slightly lower than that of controls. Geometric mean titres of HSV 1 antibody were slightly higher in inpatients, but the elevation was not significant. Furthermore, schizophrenic inpatients were subclassified into 295-0, 295-1, 295-2, 295-3 according to ICD-9-CM, and the serum prevalence and the geometric mean titres of HSV 1 antibody in each subgroup were compared with those of controls. No significant differences emerged between subgroups of schizophrenic inpatients and controls. The hypothesis schizophrenia through viral infection was discussed.