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冠動脈疾患(CAD)に対して,長期集団運動療法(平均70±48カ月)を行い,その前後に運動負荷201Tl-SPELTを施行し,心臓リハビリテーションの効果を心筋虚血の改善を中心に評価した.対象はCAD患者63名(Rh群42名,Ct群21名)で,運動療法は2-3時間/日,2-3回/週で,201Tl施行の間隔は平均19±16カ月であった.運動耐容能は運動時間で示すと,平均19%(Ct群10.7%短縮)の有意な延長を示した(p<0.01).運動負荷時の最大二重積も32.7%(Ct群1.0%低下)の増加を示した(p<0.01).201T1の灌流改善を54.8%(Ct群9.5%)に認めた(早期像59.5%,遅延像35.7%).201Tl像の灌流異常は68区域(23.1%)から49区域(16.7%)(Ct群26.8%から29.9%)に減少した.2年以上運動療法に参加した患者は201Tlの灌流改善が有意に高かった(p<0.05).以上より心臓リハビリ後,運動耐容能と201Tl画像上での灌流異常の改善が明らかになった.これらの結果より総合して,長期心臓リハビリはCAD患者に有効な治療と考えられた.
The effect of cardiac rehabilitation (mean 70±48 months) on myocardial perfusion was assessed using thallium-201 (201T1) exercise study in 63 patients with coronary artery disease (CAD). Subjects were those in a rehabilitation group (Rh=42) participating in super-vised sports training two to three times per week and the control group (Ct=21) not taking active daily exercise. The interval between two 201T1 SPECTstudies was 19±16 months. After physical training, total duration of the exercise test increased from 443± 112 to 536±121 seconds (+19%) in the Rh group, and from 481±129 to 432±115 seconds in the Ct group (-10.7%) (p<0.01). Peak double products increased from 203.4 ± 72×102 to 269.8±58x10' in the Rh group and decreased from 218.7±40×102 to 216.6±76×102 (p<0.01) in the Ct group. 201Tl myocardial perfusion defect on exercise improved more in 54.8% (stress 59. 5%, rest 35.7%) in the Rh group than in the Ct group (9. 5%, p<0.01). 201T1 perfusion defect decreased from 68 (23.1%) to 49 regions (16.7%) of 294 total myocardial regions in the Rh group on exercise. However, it in-creased from 39 (26.5%) to 44 (29.9%) regions of 147 regions in the Ct group (p<0.01). Thus, cardiac rehabil-itation increases exercise tolerance with improvement of myocardial perfusion, suggesting that cardiac reha-bilitation is an advisable and effective treatment for patients with ischemic heart disease.
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