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Japanese

Electrophysiologic effects of intravenous Cibenzoline succinate, a new classIantiarrhythmic agent Hirotsugu Atarashi 1 , Keiko Iida 1 , Mototetsu Kou 1 , Yoshiyuki Hirayama 1 , Masamichi Gotoh 1 , Takeshi Ino 1 , Takao Katoh 1 , Hirokazu Hayakawa 1 1The 1st Department of Internal Medicine, Nippon Medical School pp.1119-1124
Published Date 1988/10/15
DOI https://doi.org/10.11477/mf.1404205348
  • Abstract
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Electrophysiologic effects of cibenzoline (1.4 mg/ kg/3 min), a new class I antiarrhythmic agent, were investigated in 9 patients with PSVT inclu-ding WPW syndrome and 5 patients with ventri-cular tachycardia.

Cibenzoline significantly shortened sinus cycle length (823±120 to 751=154 msec : p<0.05) (mean= SD), and prolonged HV interval (41=9 to 54±10 msec : p<0.01). V-A conduction time were also significantly prolonged at cycle length of 550 msec (p<0.05), 460 msec (p<0.01), and 400 msec (p< 0.01). But cibenzoline revealed no consistent effects on sinus node recovery time, sinoatrial conducion time, AH interval, and effective and functional re-fractory period of right atrium, AV node and right ventricle.

Preventive effect of cibenzoline on induction of PSVT was obtained in 2 out of 6 patients (33.3%) by atrial electrical stimulation method. The plasma levels of cibenzoline ranged from 1922 to 7724 ng/ ml at the end of infusion and 156 to 533 ng/ml during the following investigation period, respecti-vely. Plasma elimination half-life was ranged from 4.4 to 12.9 hours (7.0=2.4 hours).

In conclusion, cibenzoline has potent class I effects in prolonging HV interval and effects on PSVT appear to be due to the blockade or prolongation of V-A conduction.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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