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A case of primary amyloidosis with orthostatic hypotension Hitoshi Ookuwa 1 , Shigeo Takata 1 , Nobuo Iwase 1 , Hiroshi Kida 1 , Takayuki Ikeda 1 , Nobu Hattori 1 , Tatsuho Sugimoto 2 , Masakazu Yamamoto 2 , Yuusei Annen 2 1The First Department of Internal Medicine, School of Medicine, Kanazawa University 2The Internal Medicine, Tonami City Hospital pp.679-683
Published Date 1987/6/15
DOI https://doi.org/10.11477/mf.1404205081
  • Abstract
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Autonomic nerve function was investigated in a patient with primary amyloidosis and orthostatic hypotension. There was a striking reduction of beat-to-beat variation in heart rate with deep brea-thing. Heart rate responses to phenylephrine and atropine were absent. Pressor response to phenyle-phrine was normal. Increments of heart rate during 60 passive tilt and sustained handgrip were diminis-hed. Vasoconstrictor responses to Valsalva maneuv-er, cold stimulation and passive tilt were absent. Extensive amyloid infiltration of peripheral autono-mic nervous system was present at autopsy.

These results suggest that orthostatic hypotension in primary amyloidosis may occur as a result of a diffuse autonomic neuropathy.


Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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