Effects of vasodilators on pulmonary hypertension Kouhei Uotani 1 , Junichiro Mifune 2 , Kazunori Kanamori 1 , Kuniaki Taga 2 , Masami Shimizu 2 , Sensyu Hifumi 2 , Yoshifumi Takahashi 2 , Masaki Fujimura 1 , Hiroshi Azuma 2 , Takashi Tanaka 2 1The Third Department of Internal Medicine, Kanazawa University School of Medicine 2Department of Internal Medicine, Fukui Cardiac Center pp.977-983
Published Date 1986/9/15
DOI https://doi.org/10.11477/mf.1404204929
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Three different vasodilating drugs were evaluated for the treatment of pulmonary hypertension. The drugs used were an oral prostaglandin E1 delivative (OP 1206) and nifedipine which act as arterial vasodilators, and nitrates as venous vasodilators. The effects of these vasodilators were investigated in nine patients with pulmonary hypertension by monitoring blood gas analy-sis and hemodynamic changes before and after the administration of these drugs. Six among those nine patients had secondary pulmonary hypertension due to chronic lung disease, 2 due to chronic pulmonary embo-lism and 1 had primary pulmonary hypertension.

Both of arterial vasodilators, OP 1206 and nifedipine, significantly reduced pulmonary vascular resistance and pulmonary arterial pressure with increase in or without decrease in cardiac output and oxygen delivery after the administration of the drugs. In contrast, nitrates failed to reduce pulmonary vascular resistance while the cardiac output and oxygen delivery were markedly reduced. These observations suggest that the arterial vasodilators are indicated for all types of pulmonary hypertension whereas the venous vasodilators are inade-quate.

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