A microscopic study of the blood flow regulation of the microcirculation in the rabbit tenuissimus muscle Masahiro Shibata 1 , Atsushi Kawarada 1 , Akira Kamiya 1 1Research Institute of Applied Electricity, Hokkaido University pp.189-194
Published Date 1986/2/15
DOI https://doi.org/10.11477/mf.1404204824
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Effects of the local and central blood flow con-trol mechanisms by the tissue Pob2 and the autonom-ic nervous system on capillary red cell velocity and perfused capillary density were investigated in the rabbit tenuissimus muscle. Microcirculatory re-sponses to the electric stimulation of the carotid si-nus nerve were observed using a microscopic-TV recorder system at the states of different oxygen ten-sion (PO2) in Tyrode solution suffusing the mus-cle. When PO2 in the Tyrode solution was eleva-ted, capillary red cell velocity and perfused capil-lary density were decreased both at control and during stimulation but different extents. The rates of relative mean velocity change at control and peak one during stimulation, were -5.5±0.8% and -3.1±1.3% per 10mmHg PO2 changes, whereas the rates of relative perfused capillary density changes at control and during stimulation were -2.8± 4.0% and -6.2±4.4%. The differences between the changing rates at control and during stimula-tion were both significant for velocity and density (p< 0.01). Regression lines between these changing rates and PO2 levels revealed that the reflex effect on velocity and density at 20 mmHg was about 1.3 and 4.8 times enhanced at 80 mmHg respectively. These results indicated that resistance change due to the arteriolar smooth muscle contraction elicited by the sympathetic nerve discharge was significantly influenced by the ambient PO2 level. It was con-cluded that such interaction of local and central blood flow control mechanisms plays an important role for overall regulation of the microcirculation.

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