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Studies on hemoglobin oxygen dissociation in patients with congestive heart failure Naoki Taniguchi 1 , Kazunobu Yamauchi 1 , Hirohiko Furui 1 , Masafumi Koide 1 , Masato Tsuzuki 1 , Kazuhide Takami 1 , Teruo Kondo 1 , Mitsuhiro Yokota 1 , Hiroshi Hayashi 1 , Iwao Sotobata 1 1The First Department of Internal Medicine, School of Medicine, Nagoya University pp.371-375
Published Date 1985/3/15
DOI https://doi.org/10.11477/mf.1404204629
  • Abstract
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The present study was designed to evaluate theclinical significance of hemoglobin oxygen dissocia-tion curve (ODC) in patients with congestiveheart failure (CHF). Materials consisted of 14 CHF patients due to various cardiac diseases and 57 nor-mal subjects. Blood sampling was performed from the antecubital vein for the measurements of P50levels and 2,3 diphosphoglycerate (DPG) concen-trations. P50 at 37℃, pH 7.4, PCO2 0 mmHg was determined using Hemox-Analyzer.

The P50 level was higher in CHF patients than in normal subjects (28.7 mmHg vs 25.0 mmHg, p<0.005) and 2, 3-DPG concentration was higher in CHF patients than in normal subjects (17.7 μmole/gHb vs 12.8 μmole/gHb, p<0.005). A sig-nificant positive correlation was observed between 2,3-DPG concentration and P50 level in CHF pa-tients (r=0.53, p<0.01), as well as in normal subjects (r=0.52, p<0.01). In CHF patients, the greater the severity of heart failure (New York Heart Association functional classification) was, the more rightward shift in ODC was noticed. The mean values of P50 were 26.9 mmHg for class II, 27.8 mmHg for class III, and 29.0 mmHg for class IV, respectively.

A 2,3-DPG-mediated rightward shift of ODC in patients with CHF was considered as a compensa-tory adjustment to poor tissue blood flow by impair-ed cardiac output. In conclusion, the measurement of P50 levels in CHF patients seems to be useful to assess the severity of cardiac dysfunction.


Copyright © 1985, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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