末梢抵抗血管コンプライアンス

Studies on compliance of the peripheral resistance vessels in man

　動脈の弾性的性質とくに伸展性distensibilityに関する研究は主として大きい動脈について実施され，しかも，ほとんどの実験が動物の剔出動脈を用いてなされた。

　動脈管のコンプライアンスとは，容積（V）の動脈片における内圧が微小上昇（ΔP）したとき，これにともなう容積の増加（ΔV）を求め，ΔV／（V・ΔP）として表現される。しかし，指のような体の一部における動脈管系は，小動脈から細動脈まで複雑に分岐しているので，生体のままで剔出動脈における研究にみられるような，また，物理学的にみても異論のないコンプラィアンス値を測定することは到底至難の業であるが，この場合はΔV／ΔPを測定対象の組織体積で除したものとして表現できよう。

Compliances of the peripheral resistance vessels were studied in order to compare with one another among normotensives, subjects with borderline hypertension and hypertensive patients. The peripheral resistance vessels in normal healthy adults were constricted as narrow as possible by the cold pressor test or the noradrenaline infusion test and were dilated as wide as possible by heat-ing the full body. Following results were ob-tained :

1. The mean value of compliance of the peripheral resistance vessels was the greatest in normotensives, and descending order was less in subjects with borderline hypertension, and hyper-tensive patients. No significant differences were found statistically between normotensives and subjects with borderline hypertension, and be-tween subjects with borderline hypertension and hypertensive patients, but there was a significant difference between normotensives and hyperten-sive patients (p<0.01).