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Observations on Pulmonary Alveolar Structures and Phospholipids before and after Open Heart Surgery for Prosthetic Mitral Valve Replacement Isao Sakashita 1 , Tetsunosuke Matsukawa 1 , Kenichi Asano 1 1Department of Thoracic and Cardiovascular Surgery, University of Niigata, School of Medicine pp.913-917
Published Date 1969/10/15
DOI https://doi.org/10.11477/mf.1404202082
  • Abstract
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Lungs of patients operated upon for mitral insufficiency were studied morphologically and biochemically to observe the influence of cardiopulmonary bypass. Alterations of the pulmonary structures were noted in the type Ⅱ alveolar epithelial cells and the interstitiumpostoperatively. Dilatations of capillaries and interstitial edema became evident. Con-comitantly decreased number of granules containing lamellar structures, enlargement and fusing of these granules, and invasions of swolled and coarse lamellar structures to a granule forming a bulky conglomeration were notable following surgery in the type Ⅱ alveolar epithelial cells.

Ratio of wet to dry pulmonary tissues was increased pre- and postoperatively in compa-rison with the control (lung tissue derived from patients without cardiopulmonary by-pass), suggesting the presence of a tight lung in this disease. Total pulmonary phos-pholipid was found to be less even before surgical procedure, however, showed a tend-ency to increase postoperatively. No 'marked changes were observed in the fractions of phospholipid.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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