Kokyu to Junkan Volume 57, Issue 10 (October 2009)

Influence of Concomitant Diseases on NTproBNP and BNP in Outpatients with Heart Failure Akira Kuroyanagi 1 , Takeshi Shirayama 1 , Hirokazu Shiraishi 1 , Hiroaki Matsubara 1 1Division of Cardiology, Department of Medicine, Kyoto Prefectural University of Medicine Keyword: BNP , NTproBNP , 左室重量 , 腎機能 , 心機能 , left ventricular mass , chronic kidney disease , heart failure pp.1071-1077
Published Date 2009/10/15
DOI https://doi.org/10.11477/mf.1404101355
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 BNP and NTproBNP have been recognized as useful markers of heart failure. The purpose of this study was to reveal factors that increase or decrease these markers and the difference between BNP and NTproBNP in an outpatient setting. Consecutive 256 patients with cardiovascular diseases (male 151, female 105, age 69.2±11.3 y.o.) were enrolled from outpatient clinics in a single institution. BNP and NTproBNP were equally elevated along with the grade of NYHA and CKD. Multiple linear regression analysis revealed that NYHA, left ventricular mass index and estimated glomerular filtration rate were determinant factors of NTproBNP. BNP was less affected by these factors, but by the degree of NYHA. The influence of these factors should be taken into consideration when patients are evaluated with BNP or NTproBNP. Both markers are equally useful to evaluate heart failure.

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57巻10号 (2009年10月)
電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院