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要旨 症例1は58歳の男性で,主訴は胸部苦悶であった.心電図では,V1~V5誘導でST部分の上昇が認められた.99mTc-tetrofosmine心筋SPECTでは前壁,中隔から心尖部が欠損であった.冠動脈造影では,左前下行枝の中枢部に完全閉塞病変が認められた.このため,経皮的冠動脈形成術を施行したが,造影遅延やST部分の再上昇などの再潅流障害が認められた.PTCA術直後の99mTc-PYPでは,PTCA前の99mTc-tetrofosmin像で欠損が認められた前壁,中隔および心尖部に強い集積が認められた.
症例2は53歳の男性で,主訴は左前胸部痛であった.心電図ではV3~V6誘導でST部分の上昇が認められた.99mTc-tetrofosmine心筋SPECTでは前壁,中隔から心尖部において欠損が認められた.冠動脈造影では左前下行枝の中枢部に完全閉塞が認められたため,経皮的冠動脈形成術を施行したが,この症例では造影遅延やST部分の再上昇などの所見は認められなかった.術後の99mTc-PYP心筋SPECTでは,明らかな集積は認められなかった.
同様の臨床経過が認められた2症例において,再潅流障害が生じた症例において99mTc-PYPの心筋集積が認められたため,99mTc-PYPの集積は再潅流障害を反映していると考えられた.
We report two cases with acute myocardial infraction. In case 1, an electrocardiogram showed ST segment elevation in V1-5 leads. 99mTc-tetrofosmin myocardial SPECT showed defect in the anterior, septal and apex. Coronary angiography showed total occlusion of the proximal segment of the left anterior descending coronary artery. Therefore, direct PTCA was performed to achieve reperfusion. Reperfusion injury, such as slow-flow, arrhythmia and falling blood pressure during PTCA was observed. After two hours, 99mTc-PYP myocardial SPECT showed marked uptake in the anterior, septal and apex. In case 2, an electrocardiogram showed ST segment elevation in V3-6leads. 99mTc-tetrofosmin myocardial SPECT showed defect in the anterior, septal and apex. Coronary angiography showed total occlusion of the proximal segment of the left anterior descending coronary artery. Therefore, direct PTCA was performed to achieve reperfusion. In case2, reperfusion injury was not observed during PTCA. After two hours, 99mTc-PYP myocardial SPECT showed no myocardial uptake. These findings suggest that 99mTc-tetrofosmin and 99mTc-PYP myocardial SPECT might be useful for assessment of reperfusion injury during the acute phase.
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