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A Case Report of Idiopathic Dilated Cardiomyopathy with Severe Congestive Heart Failure for which Pimobendan was Effective Yoshikazu Kokubo 1 , Osamu Yamanaka 1 , Masato Sawano 1 , Riichiro Nakayama 1 , Hiromasa Suzuki 2 , Sachio Kawai 2 1Department of Cardiology, International Goodwill Hospital 2Department of Internal Medicine, Juntendo University School of Medicine Keyword: ピモベンダン , 強心薬 , 拡張型心筋症 , pimobendan , cardiotonic drug , dilated cardiomyopathy pp.101-106
Published Date 2004/1/1
DOI https://doi.org/10.11477/mf.1404100245
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Summary

 We treated a 64-year-old man who developed exertional dyspnea in 1992 (at age 54). He was admitted to our hospital after being diagnosed with heart failure. Echocardiography showed a left ventricular diastolic diameter (LVDd) of 58mm, a left ventricular ejection fraction (EF) of 34%, a left ventricular wall thickness of 7mm, and diffuse severe hypokinesis. Based on biopsy of the right ventricular subendocardial myocardium, the patient was diagnosed as having idiopathic dilated cardiomyopathy. He was discharged under treatment with a diuretic, a cardiotonic, and oxygen. An angiotensin-converting enzyme inhibitor (alacepril, 12.5mg/day) was added in 1993 (at age 55), as well as a β-blocker (carvedilol, 10 mg/day using dose escalation) in 1996 (at age 58). The patient was hospitalized again in 2001 (at age 64) due to worsening heart failure. He had cardiomegaly and deteriorated EF, for which intravenous infusion of catecholamines was ineffective. He was started on pimobendan (2.5mg/day) when his heart failure progressed to NYHA grade IV, and his symptoms began to improve when the dose was increased to 3.75mg/day. Echocardiography showed diminished LVDd from 58mm to 53mm, the left ventricular systolic diameter from 53mm to 48mm, the EF from 24% to 34%, and BNP from over 2,000pg/ml to 446.1pg/ml. The patient has since been monitored on an outpatient basis and is making satisfactory progress. We consider that the clinical course of this case in worth reporting in detail, because pimobendan is a recommendable drug even for patients with end-stage dilated cardiomyopathy which has been treated with ACE-I and β-blocker.


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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