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要旨●患者は70歳代,男性.食後の上腹部不快感を主訴に当科外来を受診した.EGDを施行したところ,胃体上部後壁に結節が集簇した7cm大の隆起性病変を認めた.胃前庭部に萎縮性変化は認めないが,胃体部は高度萎縮を示していた.ガストリン高値,抗胃壁細胞抗体陽性,ペプシノゲンI/II低下を示し,自己免疫性胃炎(A型胃炎)に合併した胃腫瘍と診断し,腹腔鏡下胃全摘術を施行した.病理組織像では,自己免疫性胃炎に合併した幽門腺腺腫内癌であった.
A 70s man visited our gastroenterology department with a complaint of postprandial upper abdominal discomfort. An esophagogastroduodenoscopy revealed a protruding lesion of 7cm in diameter that consisted of clustered nodules on the posterior wall of the upper gastric body. The gastric antrum showed no atrophic changes, but the gastric body demonstrated severe atrophy. The serum gastrin level was high, the antiparietal cell antibody test was positive, and pepsinogen I/II levels were low. The patient was then diagnosed with a gastric tumor associated with autoimmune gastritis(type A gastritis)and underwent a laparoscopic total gastrectomy. Histopathologic examination revealed an intramucosal carcinoma in the pyloric gland adenoma associated with autoimmune gastritis.
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