雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Brunner's Glands:Involvement in the Pathogenesis of Tumor-like Lesions and Duodenal Tumors Ryoji Kushima 1,2 1Department of Pathology, Shiga University of Medical Science, Otsu, Japan Keyword: 十二指腸 , Brunner腺 , 腫瘍様病変 , 腫瘍 , 腸型と胃型 pp.1617-1626
Published Date 2021/12/25
DOI https://doi.org/10.11477/mf.1403202612
  • Abstract
  • Look Inside
  • Reference

 Understanding the characteristic histological architecture of the duodenum and the pathogenesis of tumor-like lesions, benign tumors, and malignant tumors from histopathogenetic viewpoints is important for the correct diagnosis of duodenal epithelial tumorigenesis. The surface of the duodenum is covered with small intestinal-type mucosa connected to the jejunum and ileum, and Brunner's glands are present in the submucosa to the ampullary region. Some Brunner's glands are seen in the mucosa and at the base opening of small intestine crypts. Brunner's glands consist of stable cells with properties similar to those of pyloric glands in the stomach. However, these cells can self-renew and potentially differentiate into gastric foveolar epithelium by erosion or ulceration. In addition, gastric fundic gland cells(parietal and chief cells)are often observed in the duodenal mucosa and Brunner's glands. Therefore, the origin of tumor-like lesions and duodenal epithelial tumors may show a small intestinal phenotype, gastric-Brunner's glands phenotype, or mixed phenotype. We herein discuss the involvement of Brunner's glands in the tumorigenesis of duodenal epithelial lesions.


Copyright © 2021, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有