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Forefront of the Pathological Diagnosis of Duodenal Adenoma/Carcinoma Takashi Yao 1 , Karin Ashizawa 2 , Yuki Fukumura 2 , Daiki Abe 1,3 , Atsushi Ikeda 1,3 , Sho Tsuyama 2,4 , Yoichi Akazawa 3 , Taro Kurosawa 1,3 , Soh Okano 1 , Hiroya Ueyama 3 1Department of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo 2Department of Human Pathology, Juntendo University School of Medicine, Tokyo 3Department of Gastroenterology, Juntendo University School of Medicine, Tokyo 4Department of Diagnostic Pathology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan Keyword: 非乳頭部十二指腸 , 腺腫 , 腺癌 , 組織分類 , 形質発現 pp.1628-1636
Published Date 2021/12/25
DOI https://doi.org/10.11477/mf.1403202613
  • Abstract
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 NADETs(non-ampullary duodenal epithelial tumors)are different between gastric and intestinal phenotypes in terms of clinicopathological features, histogenesis, and biological behavior. NADETs are histologically classified in a similar manner as gastric or colon cancers, and each NADET is subclassified by combining cell differentiation(intestinal, gastric, gastrointestinal mixed, and unclassifiable types). Precursor lesions, i.e., adenomas, are classified into gastric, intestinal, gastrointestinal mixed, and unclassified types, wherein the gastric type is further classified into gastric(predominant), pyloric gland(predominant), fundic gland, and mixed types. This classification is considered reasonable and easy to understand.

 To clarify the peculiarities of NADETs and establish more appropriate diagnostic criteria and histological classification, the clinicopathological features, natural history, and genetic abnormalities of NADETs should be further analyzed.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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