Human Intestinal Spirochetosis Seiji Shimizu 1 , Hideo Tomioka 1 , Kiyoshi Ogiso 1 , Eiwa Ishida 2 , Takeshi Mazaki 3 , Kyohei Ikeda 1 , Hirokazu Uejima 1 , Chihiro Yokomizo 1 , Hidetaka Takashima 1 1Division of Gastroenterology and Hepatology, Osaka General Hospital of West Japan Railway Company, Osaka, Japan 2Division of Pathology, Nara Prefecture General Medical Center, Nara, Japan 3Division of Pathology, Osaka General Hospital of West Japan Railway Company, Osaka, Japan Keyword: ヒト腸管スピロヘータ症 , 腸管スピロヘータ , Brachyspira aalborgi , Brachyspira pilosicoli , 内視鏡 pp.423-430
Published Date 2018/4/25
DOI https://doi.org/10.11477/mf.1403201326
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 We experienced 43 cases of intestinal spirochetosis in our hospital. Forty-one were diagnosed based on the appearance of a “pseudo-brush border” during the microscopic analysis of biopsy or EMR specimens, and 2 were diagnosed based on the analysis of a direct smear of the intestinal fluid collected during colonoscopy. Thirty-one cases were asymptomatic and 12 were symptomatic. Biopsy was mainly obtained from polyps or erosions, and histological diagnosis were tubular adenoma with mild atypia in 13 cases, hyperplastic polyps in 8 cases, inflammatory changes in 7 cases, and hyperplastic nodules in 4 cases. Among the 12 symptomatic patients, 9 were determined to have other causes, including 3 with amebic colitis. In all the 3 cases in which other causes were not identified, colonoscopy showed edematous mucosa and erythema on semilunar folds, mainly at the right side of the colon. Two of the 3 patients complained of chronic diarrhea, and spirochetes were observed on the direct smear of the intestinal fluid aspirated during colonoscopy ; Brachyspira pilosicoli was identified by genetic analysis in both cases. An antimicrobial was administered in only 1 case, and the other cases recovered without treatment.

Copyright © 2018, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院