The Growth and Progress of Superficial Spreading Esophageal Squamous Cell Carcinoma Manabu Takeuchi 1 , Satoru Hashimoto 2 , Masaaki Kobayashi 2 , Gen Watanabe 3 , Ken-ichi Mizuno 2 , Yuichi Sato 1 , Rintaro Narisawa 2 , Yoichi Ajioka 3 , Yutaka Aoyagi 1 1Department of Gastroenterology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 2Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan 3Division of Molecular and Diagnostic Pathology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan Keyword: 表層拡大型食道癌 , まだら食道 , 発育・進展 , 食道癌 , ESD pp.1410-1417
Published Date 2012/8/25
DOI https://doi.org/10.11477/mf.1403113576
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 Forty-five lesions of SS-ESCC(superficial spreading esophageal squamous cell carcinoma)treated with ESD(endoscopic submucosal dissection) in our institutions were analyzed retrospectively compared with other ESCC(esophageal squamous cell carcinoma)whose tumor size was from 10mm to 30mm as follows ; (1) clinicopathological characteristics, (2) Multiple LVLs(Lugol-voiding lesions), (3) the frequency of synchronous, coexistant and metachronous ESCC, (4) Lugol staining of lesion in carcinoma and (5) histopathological characteristics of invasion deeper than T1a-MM.

 In SS-ESCC, the frequency of Multiple LVLs had a tendency to be high─rate as is the case of other ESCC. Moreover, about 80%of SS-ESCC revealed many reticulated Lugol staining lesions in the tumor. However, the frequency of synchronous, coexistant and metachronous secondary carcinoma in other ESCC is significantly higher than that of SS-ESCC. Histopathological findings according to invasive parts are not markedly different between SS-ESCC and other ESCC.

 Makuuchi et al. reported the hypothesis about growth and progression of SS-ESCC in which most of SS-ESCC may develop by conglutinating multicentric dysplastic epithelium in background multiple LVLs. In addition, because the frequency of synchronous and metachronous lesions in other ESCC cases is very high, the small ESCC form Multiple LVLs and may grow gradually to SS-ESCC.

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