Primary Esophageal Endocrine Cell Carcinoma of Small Cell Type, which was 4mm in Size and pT1a-MM in Invasion Depth, Report of a Case Manabu Takeuchi 1 , Masaaki Kobayashi 2 , Yoichi Ajioka 3 , Hiromichi Takahashi 2 , Yohei Aoki 2 , Masahiko Yano 2 , Akito Sato 2 , Satoru Hashimoto 2 , Shogo Okoshi 2 , Rintaro Narisawa 1 , Yutaka Aoyagi 2 1Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata, Japan 2Department of Gastroenterology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan 3Division of Molecular and Diagnostic Pathology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan Keyword: 食道内分泌細胞癌 , 食道未分化癌 , 食道小細胞癌 , NBI , ESD pp.1759-1766
Published Date 2009/10/25
DOI https://doi.org/10.11477/mf.1403101785
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 A male in his sixties undergoing conventional esophagoscopy was shown to have a reddish flat elevated lesion on the right wall of the lower thoracic esophagus. The base of the tumor arose gently and the surface of the tumor was red and smooth, covered with a non-neoplastic epithelium. Esophagoscopy after iodine staining revealed a weakly stained lesion. Circumferential folds were not observed within the lesion. EUS(20MHz)showed a hypoechoic mass lesion invading from T1a-MM to SM1. Magnifying endoscopy with NBI revealed irregularly arranged reticular microvessels(type 4R)without forming AVA. The biopsy specimen was diagnosed as endocrine cell carcinoma(small-cell type). Because preoperative CT examination revealed neither lymph node nor distant metastasis, and the lesion invaded as deep as MM-SM1, we performed ESD for the lesion in en-bloc fashion. Histologically, the tumor was diagnosed as an esophageal endocrine cell carcinoma(small-cell type), with tumor size being 4×3mm, 0-IIa, pT1a-MM, ly0, v0, HM0, VM0. Immmunohistochemically, CD56, chromogranin A and synaptophysin were positive for the tumor cells. After ESD, the patient was treated with adjuvant chemotherapy(FP 4 course), and 7 months later, lives with no recurrence.

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