Gastric Perineurioma with Subepithelial Tumor-like Appearance, Report of a Case Shigenaga Matsui 1 , Hiroshi Kashida 1 , Rie Tanaka 1 , Masaki Takayama 1 , Hiromasa Mine 1 , Teppei Adachi 1 , Yoriaki Komeda 1 , Tomoyuki Nagai 1 , Yutaka Asakuma 1 , Toshiharu Sakurai 1 , Masatoshi Kudo 1 , Takaaki Chikugo 2 , Masayuki Tsukiyama 3 1Department of Gastroenterology and Hepatology, Kinki University, Osakasayama, Japan 2Department of Pathology, Kinki University, Osakasayama, Japan 3Tsukiyama Gastrointestinal Clinic, Osakasayama, Japan Keyword: 粘膜下腫瘍 , 神経周膜腫(perineurioma) pp.1098-1106
Published Date 2017/7/25
DOI https://doi.org/10.11477/mf.1403201133
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 Gastrointestinal endoscopy was performed in a 50-year-old female for the purpose of screening. A small, elevated lesion with subepithelial tumor-like appearance was found at the gastric fornix. A depression was noted at the top of the lesion, and the depressed area looked reddish in color, having the appearance of a submucosal tumor at the gastric fornix. Biopsies were taken but the diagnosis was not definitive. Therefore, endoscopic mucosal resection was performed as a therapeutic diagnosis(total biopsy). Histologically, proliferation of bland spindle cells with ovoid-to-elongated nuclei and indistinct cytoplasm was observed. The tumor cells tended to be located around vessels in whorls of striking appearance. Immunohistochemical staining revealed that the spindle cells were positive for Glut-1 and Claudin-1 but were negative for EMA, S-100 protein, CD34, and SMA. Thus, this lesion was diagnosed as a gastric perineurioma.

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