Immunohistochemistry of Endocrine Cell Tumors of the Digestive Tract Mitsuya Iwafuchi 1 , Mika Sugai 1 , Shinya Hayashi 1 , Kimiko Azegami 1 , Kentarou Yamada 1 1Laboratory of Pathology, Medical Laboratory Science, Niigata University Graduate School of Health Sciences, Niigata, Japan Keyword: カルチノイド腫瘍 , 内分泌細胞癌 , neuroendocrine tumor , neuroendocrine carcinoma pp.1041-1050
Published Date 2017/7/25
DOI https://doi.org/10.11477/mf.1403201128
  • Abstract
  • Look Inside
  • Reference

 Although commonly called as endocrine cell tumors, carcinoid tumors and endocrine cell carcinomas of the digestive tract are different diseases and should be diagnosed distinctively based on atypical grade of tumor cells. Endocrine differentiation of carcinoid tumors and endocrine cell carcinomas is confirmed by immunohistochemistry of endocrine markers. Ki-67 stain and p53 protein stain are useful for differential diagnosis between carcinoid tumors and endocrine cell carcinomas. Vascular invasion detected by endothelial marker stain and Ki-67 index count by Ki-67 stain are used for the prediction factor of tumor behavior and prognosis. SSTR2A and mTOR expression are used immunohistochemically to predict the drug effect to carcinoid tumors, Hormone production and gastrointestinal mucous phenotypes are examined to analyse the tumor cell nature. Carcinoid tumors/endocrine cell carcinomas and non-endocrine tumors are histologically differential diagnosed by combination of endocrine marker stains and specific marker stains for non-endocrine tumors.

Copyright © 2017, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院