Stomach and Intestine(Tokyo) Volume 51, Issue 5 (May 2016)
Japanese

White Opaque Substance as Visualized Using Magnifying Endoscopy Kenshi Yao 1 , Tetsuya Ueo 2 , Munechika Enjoji 3 , Takashi Hisabe 4 , Kentaro Imamura 1 , Kazuhisa Matsunaga 5 , Toshiharu Ueki 4 , Hiroshi Tanabe 6 , Akinori Iwashita 6 1Department of Endoscopy, Fukuoka University Chikushi Hospital, Chikushino, Japan 2Department of Gastroenterology, Oita Red Cross Hospital, Oita, Japan 3Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan 4Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan 5Laboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan 6Department of Pathology, Fukuoka University Chikushi Hospital, Chikushino, Japan Keyword: 白色不透明物質(WOS) , , 大腸 , 食道 , 十二指腸 pp.711-726
Published Date 2016/5/24
DOI https://doi.org/10.11477/mf.1403200633
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 By reviewing literature, we report the clinical significance and pathogenesis of WOS(white opaque substance)as visualized using magnifying endoscopy in the gastrointestinal mucosa. The clinical significance is that the WOS morphology is useful in the differential diagnosis between cancer and non-cancer. WOS is accumulated lipid droplets within the epithelium and subepithelium. Further, we developed a fat-loading test using WOS as an optical marker. With regard to the pathogenesis of WOS, gene expression profiles in neoplasms suggest a predominance of lipid storage(lipogenesis/lipid droplet formation)over consumption(β-oxidation/excretion/lipolysis). WOS can be detected in esophageal, gastric, duodenal and large intestinal epithelial neoplasia. Accordingly, it can be present in the entire gastrointestinal tract. WOS is a novel optical marker useful in making an endoscopic diagnosis and investigating gastrointestinal disorder pathogenesis.


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基本情報

05362180.51.5.jpg
胃と腸
51巻5号 (2016年5月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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