雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Clinicopathological and Molecular-pathological Analyses of Colorectal Laterally Spreading Tumor(LST)Based on Macroscopic Subtype Classification Noriyuki Uesugi 1 , Keisuke Kawasaki 2 , Shun-ichi Yanai 2 , Makoto Eizuka 1 , Noriyuki Arakawa 1 , Ryo Sugimoto 1 , Takashi Kosaka 1 , Kazuyuki Ishida 1 , Tomonori Kawasaki 1 , Takayuki Matsumoto 2 , Tamotsu Sugai 1 1Department of Molecular Diagnostic Pathology, Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan 2Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan Keyword: 大腸LST , 肉眼亜型 , 粘液形質 , p53過剰発現 , DNAメチル化 pp.1732-1747
Published Date 2014/11/25
DOI https://doi.org/10.11477/mf.1403200053
  • Abstract
  • Look Inside
  • Reference

 Clinicopathological and molecular-pathological analyses of colorectal laterally spreading tumor(LST)was performed based on macroscopic subtype subclassification. Seventy-two cases of LST(adenoma, n=48 ; carcinoma-in-adenoma, n=24)that were endoscopically resected at Iwate Medical University Hospital and affiliated institutions were macroscopically subclassified as GH, GM, NG-F, or NG-PD, and clinicopathological, immunohistochemical(mucin phenotype and p53 overexpression), and DNA methylation analyses were performed. Clinicopathologically, the GM cases were significantly larger in size than the other subtypes. Histologically, in the cases of adenoma, a component of tubulovillous adenoma was frequently seen in the GH and GM cases. Cases with a carcinoma component were frequently observed in the GM and NG-PD cases. For the mucin phenotype, although most cases of adenoma were of the intestinal type, conversion of the mucin phenotype was observed in half of the cases of carcinoma in adenoma based on the transition from adenoma to carcinoma component. Conversion to a small intestinal mucin phenotype was frequently observed in the cases of NG-F and NG-PD. p53 overexpression was not detected either in the adenoma cases or in the adenoma component of carcinoma-in-adenoma cases, whereas it was observed in the carcinoma component of GM and NG-PD carcinoma-in-adenoma cases. Almost all the cases showed a low-methylation epigenotype on DNA methylation analysis, and conversion of DNA methylation status was not observed during the transition from adenoma to carcinoma. In comparing the adenoma cases and the adenoma component in carcinoma-in-adenoma cases, cases with the mixed mucin phenotype were significantly more frequent in the latter. In LST, clinicopathological features and the mucin phenotype differed among the macroscopic subtypes. The findings of the present study suggest that alterations in DNA methylation status are less involved in tumorigenesis and carcinogenesis in LST.


Copyright © 2014, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有