Clinicopathological and Molecular-pathological Characteristics of Minute Gastric Adenocarcinoma Noriyuki Uesugi 1 , Tamotsu Sugai 1 , Shunsuke Orikasa 1,2 , Ryo Sugimoto 1 , Masaki Endoh 2 , Kazuyuki Suzuki 2 1Division of Molecular Diagnostic Pathology, Department of Pathology School of Medicine, Iwate Medical University, Morioka, Japan 2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan Keyword: 微小胃癌 , 粘液形質 , 腫瘍グレード , β-catenin , DNAメチル化 pp.794-808
Published Date 2013/5/25
DOI https://doi.org/10.11477/mf.1403113830
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 Background and aims : Our aim is to clarify the significance of clinicopathological and molecular-pathological characteristics of minute gastric adenocarcinomas, compared with non-minute gastric adenocarcinomas. Material and methods : Eighty-six minute gastric adenocarcinomas and 83 non-minute gastric adenocarcinoma obtained by endoscopic submucosal dissection were examined. We histologically examined clinicopathological features, tumor grades, findings of back-ground mucosa and mucin phenotype, immunohistochemically. Immunohistochemical analysis for p53, MLH-1 and beta-catenin were also performed. Furthermore, DNA methylation status of cancer and back-ground mucosa were classified using nine genes(LOX, MINT31, RUNX3, ELMO1, THBD, NEUROG1, SOCS1, p16, hMLH1)according to 2 panel methods of Yagi et al. Results : In minute gastric adenocarcinoma, (1) lower gastric location, (2) IIb macroscopical finding and (3) low grade cancer, were more frequently found compared with non-minute adenocarcinoma. Although there were no significant differences in expression of p53 and MLH-1, intranuclear accumulation of beta-catenin were more frequently found in minute adenocarcinoma. There were no significant differences for positive-rate and intraglandular distribution of Ki-67 positive cells. Low DNA methylation status was frequently found in minute gastric adenocarcinoma and high DNA methylation status was less frequent in minute gastric adenocarcinoma than non-minute gastric adenocarcinoma. There were no significant differences for DNA methylation status of back-ground mucosa between minute and non-minute adenocarcinoma. Conclusions : We could clarify there are the differences in accumulation of DNA methylation between minute and non-minute gastric adenocarcinomas.

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