Two Types of Neoplasia in Fundic-Gland Mucosa without Helicobacter pylori Infection : Gastric Carcinoma and Polyp with Dysplasia Takashi Yao 1 , Hiroya Ueyama 2 , Tetsuya Ueo 3 , Yasuhiro Hidaka 2 , Ryosuke Nomura 2 1Department of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo 2Division of Gastroenterology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo 3Department of Gastroenterology, Oita Red Cross Hospital, Oita, Japan Keyword: 胃底腺型胃癌 , 胃底腺ポリープ , 幽門腺腺腫 , Wntシグナル , βカテニン pp.874-880
Published Date 2014/5/25
DOI https://doi.org/10.11477/mf.1403114175
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 There is a type of gastric carcinoma of the fundic gland that is not associated with Helicobacter pylori(H. pylori)infection. This gastric carcinoma is believed to be a low-grade tumor with favorable prognosis, but there are reports of high-grade tumors. A mutation in the GNAS gene and activation of the Wnt signaling pathway are possibly associated with the development and progression of such tumors. Further research is needed to elucidate the cytological and molecular factors related to the biological behavior, which may predict the response to treatment. A FGP(fundic gland polyp)is not associated with H. pylori infection either and is believed to carry no risk of malignancy. Recently, FGP is suggested to become neoplastic due to a β-catenin gene mutation even in sporadic cases. FGPs with neoplastic transformation have also been reported. In the future, the H. pylori infection rate will be decreasing ; thus, it is necessary to draw more attention to the new risks of these 2 types of lesions in the fundic gland mucosa.

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