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要旨 早期胃癌に対するESDが一般化し,その適応も拡大されつつある.これに伴い,より厳密な内視鏡による範囲診断,深達度診断がより重要となっている.今回,表層が低異型度分化型胃癌で覆われ,粘膜深層とSM浸潤部が低分化腺癌であり,深達度診断に苦慮した症例を経験したので報告する.患者は70歳代,男性.上部消化管内視鏡検査にて,胃角部小彎を中心とした径50mm大で顆粒・結節集簇様の扁平隆起性病変を認め,通常内視鏡観察,EUSともに明らかなSM深部浸潤の所見が得られなかったため,深達度T1aと診断し,ESDを施行した.病理組織学的には,粘膜深部から粘膜下層で低分化腺癌へ移行する粘膜下層深部浸潤癌であった.
A man in his 70's was admitted to our hospital for the treatment of gastric carcinoma. The gastric carcinoma showed on 0-IIa lesion, 50mm in diameter. After we diagnosed the gastric carcinoma as an intramucosal carcinoma according to conventional endoscopy and endoscopic ultrasonography, we performed endoscopic submucosal dissection. The pathological diagnosis was low-grade differentiated-type adenocarcinoma invading to the submucosal layer with poorly differentiated adenocarcinoma(tub1>por2>tub2, pT1b2(SM 3,500μm), ly(-), v(-), pHM0, pVM1). Because we considered that the specimen resected by endoscopic submucosal dissection was non-curative, we performed additional surgical resection. This case suggested that the diagnosis should be performed based not only on conventional endoscopy and endoscopic ultrasonography but also on X-ray examination.
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