Undetermined Chronic Colitis with Prominent Eosinophilic Infiltration, Report of a Case Koichi Abe 1 , Kunihiko Aoyagi 1 , Satoshi Nimura 2 , Yoshitaka Tomioka 1 , Masashi Yamaguchi 1 , Koichi Eguchi 1 , Akinori Iwashita 3 , Shotaro Sakisaka 1 1Department of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan 2Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan 3Department of Pathology, Fukuoka University Chikushi Hospital, Chikushino, Japan Keyword: 好酸球浸潤 , 顆粒状粘膜 , 好酸球性胃腸炎 , 炎症性腸疾患 , アレルギー pp.1945-1952
Published Date 2013/12/25
DOI https://doi.org/10.11477/mf.1403114029
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 A-26-year old woman was admitted to our hospital with abdominal pain, diarrhea and hematochezia. Colonoscopy revealed diffuse granular mucosa from cecum to sigmoid colon, and the biopsy specimens demonstrated prominent eosinophilic infiltration. The diseased area was limited to the large intestine with neither endoscopic nor pathological findings both in upper gastrointestinal tract and the small intestine. Eosinophilic colitis could be suggested according to the diagnostic criteria(Talley et al. and Kinoshita et al.). However, the disease other than so-called eosinophilic colitis was considered because macroscopic findings are granular mucosa but not erythema, edema and erosion, and pathological findings show a severe and diffuse inflammatory infiltrate without an intraepithelial infiltrate. Although allergic colitis could not be denied, various food allergic tests were all negative. Careful consideration is required in the diagnosis of colitis with an eosinophilic infiltrate with reference to various disorders. Especially, undetermined colitis could progress to typical inflammatory bowel disease.

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